GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs7116495 | 1 | rs7121260 | chr11:71700566 | FAM86C | chr11:71498557-71512276:+ | 0.28 | 3.55 | 0.000418 | Severe influenza A (H1N1) infection |
| THCA | cis | rs7112513 | 1 | rs7121347 | chr11:116867209 | PCSK7 | chr11:117075789-117102811:- | -0.28 | -5.03 | 7.12E-7 | Protein quantitative trait loci |
| THCA | cis | rs1834481 | 1 | rs7121554 | chr11:112048051 | BCO2 | chr11:112046208-112095421:+ | 0.24 | 4.89 | 1.37E-6 | Interleukin-18 levels |
| THCA | cis | rs1834481 | 1 | rs7121554 | chr11:112048051 | IL18 | chr11:112013976-112034840:- | -0.23 | -4.36 | 1.62E-5 | Interleukin-18 levels |
| THCA | cis | rs3802842 | 1 | rs7122375 | chr11:111171071 | C11orf92 | chr11:111164171-111175770:- | -0.18 | -3.98 | 8.02E-5 | Colorectal cancer |
| THCA | cis | rs7112513 | 1 | rs7122944 | chr11:117034619 | PCSK7 | chr11:117075789-117102811:- | -0.39 | -6.84 | 2.39E-11 | Protein quantitative trait loci |
| THCA | cis | rs7112513 | 1 | rs7123517 | chr11:117027755 | PCSK7 | chr11:117075789-117102811:- | -0.4 | -6.89 | 1.74E-11 | Protein quantitative trait loci |
| THCA | cis | rs11026091 | 1 | rs7123908 | chr11:3260189 | MRGPRE | chr11:3249042-3253616:- | -0.19 | -3.69 | 0.000253 | Multiple sclerosis |
| THCA | cis | rs7116495 | 1 | rs7124000 | chr11:71754338 | FAM86C | chr11:71498557-71512276:+ | 0.3 | 3.8 | 0.000166 | Severe influenza A (H1N1) infection |
| THCA | cis | rs7112513 | 1 | rs7124741 | chr11:116752219 | PCSK7 | chr11:117075789-117102811:- | -0.27 | -4.68 | 3.79E-6 | Protein quantitative trait loci |
| THCA | cis | rs983392 | 1 | rs7124974 | chr11:59906972 | MS4A14 | chr11:60145958-60185226:+ | 0.18 | 4.47 | 9.6E-6 | Alzheimer's disease (late onset) |
| THCA | cis | rs79243044 | 1 | rs7125746 | chr11:5556005 | UBQLNL | chr11:5535624-5537956:- | -0.28 | -6.5 | 2.07E-10 | QRS duration in Tripanosoma cruzi seropositivity |
| THCA | cis | rs11026412 | 1 | rs7126396 | chr11:22130513 | ANO5 | chr11:22214722-22304913:+ | 0.29 | 5.69 | 2.17E-8 | Parkinson's disease |
| THCA | cis | rs7107174 | 1 | rs7127187 | chr11:77995188 | NARS2 | chr11:78147017-78285909:- | -0.37 | -6.78 | 3.47E-11 | Testicular germ cell tumor |
| THCA | cis | rs7951870 | 1 | rs7127529 | chr11:46582072 | PACSIN3 | chr11:47199085-47207958:- | 0.16 | 3.59 | 0.000359 | Schizophrenia |